Question

como passar para o interrogativo e o negativo as seguintes frases:
he studies spanish.
my friend studies prtuguese.
mary studies with my sister.
jhn and michel study with brother.
michael studies english.

Answer 1

Para a terceira pessoa do singular, usa-se a partícula "does" para formar frases interrogativas e negativas. Assim:

He doesn't study spanish.
Does he study spanish?

My friend doesn't study portuguese.
Does my friend study portuguese?

Mary doesn't study with my sister.
Does Mary study with my sister?

John and Michel DON'T study with brother. (They don't study with brother.)
Do John and Michel study with brother?

Michael doesn't study english.
Does Michael study english?

EXPLICANDO:
I do (not)
You do (not)
He / she / it does (not)
We do (not)
You do (not)
They do (not)